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Autoimmunity is on the Rise by Pursue Wellness Autoimmunity is on the rise in the United States. Collectively, autoimmune disorders are one of the most prevalent diseases in the US and affect up to 10% of the US population, or an estimated 24 million people. Autoimmune diseases are a pathophysiological state wherein immune responses are directed against and damage the body’s own tissue. Your immune system can no longer tell the difference between healthy cells and microorganisms. Disease defenses that once protected them are instead attacking their own tissue and organs. Regulatory T cells (T Lymphocytes) regulate or suppress other cells in the immune system. In autoimmune diseases, these T cells fail to control the immune system and can exaggerate immune responses. Researchers have found a 44% increase in ANA, the autoantibody (antibodies that target self) in lupus, in the last 25 years, with 41 million people affected. Inflammation is closely associated with autoimmune diseases along with other symptoms like fatigue, joint pain, skin issues (rash, hives etc.) and gastrointestinal issues.